Comparison of foley's catheter with extra amniotic prostaglandin F2 alpha in termination of second trimester pregnancy

The aim of this study was to compare the efficacy, safety, adverse effects and cost effectiveness of extra-amniotic Foley's catheter balloon alone [group-I], with the combined use of Foley's catheter balloon and extra-amniotic prostaglandin F2-alpha [group-Il] for termination of second trimester pregnancy. It was a experimental trial carried out in Obstetrics and Gynecology unit "A" of post-graduate medical institute, Lady Reading Hospital Peshawar, during September 2002 to September 2003. Hundred [100] patients having gestational age between 14-28 weeks and cervical score less than 4, were enrolled in the study, 50 patients for group-I and 50 patients for group-Il. Indications for termination were either intrauterine fetal death or congenital malformations incompatible with life. Foley's catheter 16fr was passed in both the groups intra-cervically. Group-Il patients in addition received extra amniotic PGF2 alpha, [0.25 mg/ml diluted solution], one ml at one hour interval, through the same catheter, till the expulsion of the balloon. The mean induction to products expulsion interval was significantly shorter in the combined use of Foley's catheter and extra amniotic PGF2 alpha [13.34 +/- 6.71 versus 33.74 +/- 8.941 hours]. The rate of successful uterine expulsion with in 24 hrs was also significantly higher in group-11 [92% versus 24%]. The frequency of diarrhea [04%], vomiting [06%,], and uterine pain [06%] in group -11 was not statistically significant [P > 0.05] but the frequency of temperature of 100 F was significantly higher in group-1 [78%] as compared to group-11 [18% Group-11 patients had shorter average hospital stay [1.53 +/- 0.57 days versus 2.766 +/- 0.567 ingroup-1 i.e. P < 0.1]. The combined use of Foley's catheter and extra amniotic PG F2 alpha is more rapid, safe, cost effective method for induction of therapeutic termination of second trimester pregnancy, resulting in greater number of successful uterine evacuation with in 24 hrs, than Foley's catheter balloon alone

Usefullness of 100 microgram misoprostol in term gravid patients regarding Labour, fetal and maternal outcome

To determine the effect of 100 microgram misoprostol for induction of labour in term gravid patients regarding, labour, fetal, and maternal outcome. Descriptive study was carried out in the Gyne [A] Unit of PGMI/Lady Reading Hospital Peshawar, from June 2005 to February 2006. A total of 100 admitted patients were selected for the study in whom 100 microgram Misoprostol was administered orally. Labour was induced in selected patients and post delivery complications were recorded. The age range of patients was from 15-39 years. Out of 100 gravid patients, primigravida were 63%. In 83% of patients pre-induction cervical scoring was <4 while 4-7 in 17% patients. Indications for induction of labour were; raised blood pressure 40%, post dates 35%, intrauterine fetal death 11%, LU.G.R.10% and diabetes mellitus 4% cases. Misoprostol 100 microgram was given as one dose to 37% women, 2 doses to 44% women, 3 doses to 13% women, while 4 doses were given to 6% women. Normal vaginal delivery was done in 68% cases. Instrumental delivery was done in 30% cases, while cesarean section was done in 2% cases due to fetal distress. Majority of patients [69%] delivered within 24 hours. Stay in the hospital was 2 days in 42%, 3-4days in 48%, and 5-6 days in 10% of cases. Maternal complications included nausea/vomiting in 61% cases and postpartum hemorrhage in 1%. Fetal low APGAR score was observed in 6% cases. Oral misoprostol is an attractive alternative for induction of labour in patients with full term pregnancy

Successful pregnancy outcome following chemotherepy for choriocarcinoma

This case report describes a twenty-two years old woman with successful pregnancy outcome following Chemotherapy for Choriocarcinoma

Identification of sensitive and specific markers for typhoid fever: the rapid detection

Typhoid fever is common in Pakistan and several developing countries, especially among children. There has been a continuous search for a simple and reliable test that can be carried out in a small laboratory, for an early and rapid diagnosis. For this purpose, Typhidot test and TUBEX test have been evaluated in the present study. Blood samples from 131 patients with age range of 2-10 years presented with 4 days of fever. The patients were recommended for the detection of 1gM and IgG antibodies to Salmonella typi. Typoidot test was positive for both IgG and 1gM antibodies to S. typhi in our samples. Typhidot test gave a sensitivity of 100 percent and specificity of 80 percent when bacteraemic patients were analyzed. It has been concluded that the Typohidot is a quick and easy-to-perform test that requires no special equipment and training of staff for interpretation of results. The ELISA results for 1gM and IgG were more sensitive and specific than any combination of the Widal test, and hence it could be a useful tool for the serologic diagnosis of typhoidal fever with a single blood sample

effect of different fertilizers [urea, diammonium phosphate and mixed] on growth, oil and cake contents of two varieties of linum usitatissimum Linn

The effect of different fertilizers [urea, di-ammonium phosphate and mixed] on growth behaviour, and oil contents of seeds of Linum usitatissimum were studied. The plants were of the height of 45.0 and 27.30 cms treated with urea in both the verieties. The number of capsules were 180 and 75 per plant and oil percentage was 44.0 and 41.0, that was maximum in plant treated with mixed [di-ammonium phosphate + urea] in both the varieties. But the percentage of cake was maximum [68.40 and 73.0] in control in both the varieties of plant in pot and field experiments simultaneously